The major research aims of the Aerosol Research Group include the evaluation of the efficacy of therapeutic aerosols and exposure to environmental aerosols in paediatric respiratory disease.
Efficient delivery of inhaled drug therapy is problematic for paediatric respiratory patients, particularly in the infant and preschool years.
Our research focuses on the:
Research will continue into the development of an ex-vivo model using flow-volume simulation to predict total drug delivery and airway deposition. Future directions in research for the Aerosol Group include the elucidation of optimal conditions for deposition of therapeutic aerosols in infants and toddlers, including inspiratory parameters and particle size characteristics.
Asthma genetics investigates the effects of inhaled environmental particulate exposure on the development of asthma and atopy in vivo, and at the molecular level (through the development of physiological aerosol exposure systems for human bronchial epithelial cell cultures). The measurement of in-vivo exposure of children during gestation and early life, to environmental tobacco smoke and other particulate exposures is also being investigated.