School of Paediatrics and Child Health

The genetics of vaccine responses in children

Further information


Vaccines have been the major contributing factor to preventing childhood illness in the past 100 years. 


Considerable differences in responses to vaccines have been noted between individuals and populations. Given the high pro-Th2 allele frequency in tropical developing countries this raises many concerns regarding vaccine efficacy that are being explored.


Results from our studies on pneumococcal, diphtheria and tetanus vaccines have shown pro-Th2 immune response alleles are associated with substantially reduced vaccine-specific IgG antibody production and impaired vaccine-specific peripheral blood mononuclear cell responses. These effects are much worse in children exposed to environmental tobacco smoke. 



School of Paediatrics and Child Health

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Last updated:
Thursday, 14 March, 2013 9:26 AM