School of Paediatrics and Child Health

CNRE Current Clinical Trials

Clinical trials

The CNRE is actively involved in several clinical trials currently running at the King Edward Memorial Hospital and Princess Margaret Hospital.


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Interventional studies


 

Pentoxifylline to PROTECT the preterm brain (PROTECT)

PROTECT is an international multi-centre randomised controlled trial aiming to evaluate the effect of reducing long-term disability with intravenous pentoxifylline versus placebo in babies born < 29 weeks gestational age with sepsis or necrotizing enterocolitis.

  • Target population: Babies born less than 29 weeks gestational age with suspected blood or gut infection
  • ANZCTR registry number: ACTRN12616000405415

 

Enteral Vitamin A to Improve Respiratory Outcomes (EVARO)

EVARO is a single-centre randomised controlled trial that aims to evaluate the efficacy of Vitamin A supplement in decreasing the severity of bronchopulmonary dysplasia (BPD, a type of chronic lung disease).

  • Target population: Babies born less than 28 weeks gestational age without congenital gastrointestinal and respiratory tract abnormalities
  • ANZCTR registry number: ACTRN12616000408482


Erythropoietin for Neonatal Hypoxic-Ischaemic Encephalopathy (PAEAN)

PAEAN is a multi-centre randomised controlled trial to evaluate the effect of intravenous Erythropoietin (Epo) in improving neurodevelopmental outcomes at 2 years of age in term infants with hypoxic-ischaemic encephalopathy (HIE). 

  • Target population: Babies born greater than 35 weeks gestational age with moderate-severe HIE
  • ANZCTR registry number: ACTRN12614000669695


Probiotics for newborn babies with surgical conditions of the gut (PRINS)

The PRINS trial is a single-centre randomised controlled trial aiming to evaluate the effect of oral probiotics in improving intestinal bacterial and overall health in newborn babies with gastrointestinal anomalies requiring surgery.

  • Target population: Babies born greater than or equal to 35 weeks gestational age with major congenital gastrointestinal anomalies
  • ANZCTR registry number: ACTRN12617001401347

 

 

Observational studies


 

Preterm Infant Functional and Clinical Outcomes Study (PIFCO)

The PIFCO study aims to attain a more complete understanding of the interrelationships between severity of lung disease, weakness of the muscle pump and the interplay between the lungs and the circulatory system (specifically, the circulation components responsible for gas exchange in the lungs). 

  • Target population: Babies born less than 32 weeks gestational age without complex congenital abnormalities and diaphragmatic hernia
  • ANZCTR registry number: ACTRN12613001062718

 

Lung Ultrasound 

The lung ultrasound study is a single centre observational trial to determine the predictive value of bedside lung ultrasound in preterm babies with respiratory distress and evolution of bronchopulmonary dysplasia (BPD).

  • Target population: Babies born less than 28 weeks gestational age receiving any modality of respiratory support
  • ANZCTR registry number: ACTRN12617000208303

 

Developmental differences in circadian rhythm establishment in preterm and term infants (CircaDiem)

Circa Diem is a single centre observational pilot study to investigate the establishment of circadian rhythm of cortisol, melatonin, and other physiological parameters in preterm and term infants.

  • Target population: 40 babies born 24 weeks to less than 41 weeks gestational age
  • ANZCTR registry number: ACTRN12617000346370


 

School of Paediatrics and Child Health

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Last updated:
Wednesday, 15 November, 2017 9:54 AM

http://www.paediatrics.uwa.edu.au/3041734