School of Paediatrics and Child Health

Lauren Mott

Contact

Lauren Mott

School of Paediatrics & Child Health
M561
The University of Western Australia
Princess Margaret Hospital for Children
PO Box D 184, Subiaco
WA 6840

Phone (+61) 9340 8606
Fax (+61) 9388 2097

Supervisors

Start Date

March 2008

Submission Date

August 2013

Lauren Mott

Thesis

Computed tomography assessment of early structural lung disease in young children with cystic fibrosis.

Summary

Chest computed tomography (CT) is a promising endpoint that reflects altered lung structure in infants with cystic fibrosis. The global objective of the research presented in this thesis was to contribute to the development of chest CT as a suitable endpoint for cystic fibrosis clinical trials commencing in infancy, demonstrating the ability to reflect progressive lung disease, and contributing to standardisation of acquisition protocols. The results support the use of chest CT to monitor progression of lung disease in early childhood. Chest CT can now be considered a suitable endpoint for clinical trials commencing in infancy. 

Why my research is important

Early structural lung disease is an important outcome measure for clinical trials aimed at preventing or delaying the onset of early lung disease in infants with cystic fibrosis. The research presented in this thesis will contribute to the development of chest computed tomography as an outcome measure for clinical trials commencing in infancy. 

Funding

  • National Health and Medical Research Council Medical and Dental Postgraduate Scholarship
  • Athelstan and Amy Saw Medical Research Fellowship
  • Cystic Fibrosis Western Australia Postgraduate Studentship
  • Cystic Fibrosis Australia Postgraduate Studentship
 

School of Paediatrics and Child Health

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Last updated:
Monday, 1 September, 2014 2:21 PM

http://www.paediatrics.uwa.edu.au/2589305