School of Paediatrics and Child Health

Thomas Iosifidis

Thomas Iosifidis 

Contact

Thomas Iosifidis

School of Paediatrics & Child Health
M561
The University of Western Australia
Princess Margaret Hospital for Children
PO Box D 184, Subiaco
WA 6840

Phone (+61) 9340 8625
Fax (+61) 9388 2097

Supervisors

Start Date

January 2013

Submission Date

January 2016


Thomas Iosifidis

Thesis

Defective cell migration as a mechanism of dysregulated asthmatic airway repair.

Summary

Asthma affects ~16% (> 300,000) of children in Australia. The highest rate of hospital separations for asthma is in children. Despite advances in our understanding of asthma, currently available therapies fail to alter the natural history and progression of the disease.

Our research group and others have shown that the epithelium is intrinsically altered both structurally and biochemically in asthma, reflecting an increased susceptibility to injury and inadequate repair response. Importantly, many of these characteristics can be detected early in disease progression and correlate with severity such as aberrant wound repair of asthmatic epithelium. We believe that a failure of the epithelium to repair appropriately in asthma is an important component of an asthma endotype that renders the epithelium susceptible to injurious environmental triggers such as viruses and that can contribute to a chronic inflammatory response and remodelling in the airways.

The aim of this study is to investigate the mechanisms regulating the defective cell migration and repair in asthmatic paediatric airway epithelium. Subsequently, the functional significance of deregulated pathways of interest will be examined in the pathogenesis of asthma.

Why my research is important

It is essential to understand the complex regulatory mechanisms involved in epithelial repair and to identify novel mechanisms and potential therapeutic targets. The study is tightly focused on understanding the basic mechanisms associated with abnormal repair in asthma with a view to developing a new class of therapies that restore epithelial function and integrity.

Funding

  • Australian Postgraduate Award and UWA Safety Net Top Up Scholarship
  • Centre for Cell Therapy and Regenerative Medicine PhD Top Up Scholarship


 

School of Paediatrics and Child Health

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Last updated:
Monday, 1 September, 2014 3:10 PM

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